Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis.
Identifieur interne : 00BC76 ( Main/Exploration ); précédent : 00BC75; suivant : 00BC77Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis.
Auteurs : S. Mahanty [États-Unis] ; H E Luke ; V. Kumaraswami ; P R Narayanan ; V. Vijayshekaran ; T B NutmanSource :
- Experimental parasitology [ 0014-4894 ] ; 1996.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Adolescent, Adulte, Animaux, Antigènes d'helminthe (immunologie), Brugia malayi (croissance et développement), Brugia malayi (immunologie), Cytokines (biosynthèse), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Humains, Interféron gamma (biosynthèse), Interleukine-10 (biosynthèse), Interleukine-2 (biosynthèse), Interleukine-4 (biosynthèse), Interleukine-5 (biosynthèse), Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Microfilaria (immunologie), Mâle.
- MESH :
- biosynthèse : Cytokines, Interféron gamma, Interleukine-10, Interleukine-2, Interleukine-4, Interleukine-5.
- croissance et développement : Brugia malayi.
- immunologie : Antigènes d'helminthe, Brugia malayi, Filariose lymphatique, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Microfilaria.
- parasitologie : Filariose lymphatique.
- Activation des lymphocytes, Adolescent, Adulte, Animaux, Femelle, Humains, Mâle.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antigens, Helminth (immunology), Brugia malayi (growth & development), Brugia malayi (immunology), Cytokines (biosynthesis), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Female, Humans, Interferon-gamma (biosynthesis), Interleukin-10 (biosynthesis), Interleukin-2 (biosynthesis), Interleukin-4 (biosynthesis), Interleukin-5 (biosynthesis), Lymphocyte Activation, Male, Microfilariae (immunology), Th1 Cells (immunology), Th2 Cells (immunology).
- MESH :
- chemical , biosynthesis : Cytokines, Interferon-gamma, Interleukin-10, Interleukin-2, Interleukin-4, Interleukin-5.
- chemical , immunology : Antigens, Helminth.
- growth & development : Brugia malayi.
- immunology : Brugia malayi, Elephantiasis, Filarial, Microfilariae, Th1 Cells, Th2 Cells.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Female, Humans, Lymphocyte Activation, Male.
Abstract
Parasite stage-specific T cell responses were studied in Indians with lymphatic filariasis manifesting as elephantiasis (CP, n = 11) and asymptomatic microfilaremia (MF, n = 8), using antigens derived from the microfilarial, adult male only, and mixed adult male and female worms. Proliferative responses to microfilarial and mixed (male-female adult worm) antigens in MF individuals were markedly impaired compared to corresponding responses in individuals with CP. In contrast, T cell proliferative responses to adult male-derived antigens were not statistically different between the two groups. Analysis of antigen-driven cytokine secretion by peripheral blood mononuclear cells from MF and CP individuals revealed significantly lower IL-2 and IFN-gamma production by MF in response to microfilarial and mixed antigens (but not to adult male antigen) compared to CP individuals. No differences were observed between MF and CP in parasite antigen-driven IL-4 or IL-5 production. Spontaneous and parasite-specific IL-10 secretion was also measured to determine if cytokine cross-regulation of Th1 responses may be a mechanism underlying the observed Th1 suppression. Spontaneous and microfilarial antigen-driven IL-10 was found to be significantly higher in MF than in CP individuals. These data indicate that MF individuals exhibit preferentially impaired Th1-type responses to microfilarial antigens and that microfilarial-induced IL-10 may be critical in the downregulation of specific Th1 responses.
DOI: 10.1006/expr.1996.0114
PubMed: 8932778
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 005105
- to stream PubMed, to step Curation: 005105
- to stream PubMed, to step Checkpoint: 005105
- to stream Ncbi, to step Merge: 00B879
- to stream Ncbi, to step Curation: 00B879
- to stream Ncbi, to step Checkpoint: 00B879
- to stream Main, to step Merge: 00C478
- to stream Main, to step Curation: 00BC76
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis.</title><author><name sortKey="Mahanty, S" sort="Mahanty, S" uniqKey="Mahanty S" first="S" last="Mahanty">S. Mahanty</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Luke, H E" sort="Luke, H E" uniqKey="Luke H" first="H E" last="Luke">H E Luke</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Narayanan, P R" sort="Narayanan, P R" uniqKey="Narayanan P" first="P R" last="Narayanan">P R Narayanan</name></author><author><name sortKey="Vijayshekaran, V" sort="Vijayshekaran, V" uniqKey="Vijayshekaran V" first="V" last="Vijayshekaran">V. Vijayshekaran</name></author><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:8932778</idno><idno type="pmid">8932778</idno><idno type="doi">10.1006/expr.1996.0114</idno><idno type="wicri:Area/PubMed/Corpus">005105</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005105</idno><idno type="wicri:Area/PubMed/Curation">005105</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005105</idno><idno type="wicri:Area/PubMed/Checkpoint">005105</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005105</idno><idno type="wicri:Area/Ncbi/Merge">00B879</idno><idno type="wicri:Area/Ncbi/Curation">00B879</idno><idno type="wicri:Area/Ncbi/Checkpoint">00B879</idno><idno type="wicri:doubleKey">0014-4894:1996:Mahanty S:stage:specific:induction</idno><idno type="wicri:Area/Main/Merge">00C478</idno><idno type="wicri:Area/Main/Curation">00BC76</idno><idno type="wicri:Area/Main/Exploration">00BC76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis.</title><author><name sortKey="Mahanty, S" sort="Mahanty, S" uniqKey="Mahanty S" first="S" last="Mahanty">S. Mahanty</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Luke, H E" sort="Luke, H E" uniqKey="Luke H" first="H E" last="Luke">H E Luke</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Narayanan, P R" sort="Narayanan, P R" uniqKey="Narayanan P" first="P R" last="Narayanan">P R Narayanan</name></author><author><name sortKey="Vijayshekaran, V" sort="Vijayshekaran, V" uniqKey="Vijayshekaran V" first="V" last="Vijayshekaran">V. Vijayshekaran</name></author><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name></author></analytic><series><title level="j">Experimental parasitology</title><idno type="ISSN">0014-4894</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi (growth & development)</term><term>Brugia malayi (immunology)</term><term>Cytokines (biosynthesis)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Humans</term><term>Interferon-gamma (biosynthesis)</term><term>Interleukin-10 (biosynthesis)</term><term>Interleukin-2 (biosynthesis)</term><term>Interleukin-4 (biosynthesis)</term><term>Interleukin-5 (biosynthesis)</term><term>Lymphocyte Activation</term><term>Male</term><term>Microfilariae (immunology)</term><term>Th1 Cells (immunology)</term><term>Th2 Cells (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi (croissance et développement)</term><term>Brugia malayi (immunologie)</term><term>Cytokines (biosynthèse)</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Humains</term><term>Interféron gamma (biosynthèse)</term><term>Interleukine-10 (biosynthèse)</term><term>Interleukine-2 (biosynthèse)</term><term>Interleukine-4 (biosynthèse)</term><term>Interleukine-5 (biosynthèse)</term><term>Lymphocytes auxiliaires Th1 (immunologie)</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Microfilaria (immunologie)</term><term>Mâle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term><term>Interferon-gamma</term><term>Interleukin-10</term><term>Interleukin-2</term><term>Interleukin-4</term><term>Interleukin-5</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term><term>Interféron gamma</term><term>Interleukine-10</term><term>Interleukine-2</term><term>Interleukine-4</term><term>Interleukine-5</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Lymphocytes auxiliaires Th1</term><term>Lymphocytes auxiliaires Th2</term><term>Microfilaria</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Microfilariae</term><term>Th1 Cells</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Female</term><term>Humans</term><term>Lymphocyte Activation</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parasite stage-specific T cell responses were studied in Indians with lymphatic filariasis manifesting as elephantiasis (CP, n = 11) and asymptomatic microfilaremia (MF, n = 8), using antigens derived from the microfilarial, adult male only, and mixed adult male and female worms. Proliferative responses to microfilarial and mixed (male-female adult worm) antigens in MF individuals were markedly impaired compared to corresponding responses in individuals with CP. In contrast, T cell proliferative responses to adult male-derived antigens were not statistically different between the two groups. Analysis of antigen-driven cytokine secretion by peripheral blood mononuclear cells from MF and CP individuals revealed significantly lower IL-2 and IFN-gamma production by MF in response to microfilarial and mixed antigens (but not to adult male antigen) compared to CP individuals. No differences were observed between MF and CP in parasite antigen-driven IL-4 or IL-5 production. Spontaneous and parasite-specific IL-10 secretion was also measured to determine if cytokine cross-regulation of Th1 responses may be a mechanism underlying the observed Th1 suppression. Spontaneous and microfilarial antigen-driven IL-10 was found to be significantly higher in MF than in CP individuals. These data indicate that MF individuals exhibit preferentially impaired Th1-type responses to microfilarial antigens and that microfilarial-induced IL-10 may be critical in the downregulation of specific Th1 responses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name><name sortKey="Luke, H E" sort="Luke, H E" uniqKey="Luke H" first="H E" last="Luke">H E Luke</name><name sortKey="Narayanan, P R" sort="Narayanan, P R" uniqKey="Narayanan P" first="P R" last="Narayanan">P R Narayanan</name><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name><name sortKey="Vijayshekaran, V" sort="Vijayshekaran, V" uniqKey="Vijayshekaran V" first="V" last="Vijayshekaran">V. Vijayshekaran</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Mahanty, S" sort="Mahanty, S" uniqKey="Mahanty S" first="S" last="Mahanty">S. Mahanty</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00BC76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00BC76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:8932778
|texte= Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:8932778" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |